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NO2 and CEE Matrix for Strength

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N'Gorge Creatine Ethyl Ester Nitric Oxide Matrix
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New even more powerful NO2 matrix!

In the world of sports supplementation the same mentality often exists, and with good reason! If product A works amazingly well, and product B also works incredibly well, perhaps together they could produce effects never seen before! Recently this idea has been applied to two of the most effective muscle-building/performance enhancing compounds in the industry...CEE (creatine ethyl ester) and nitric oxide (NO2) potentiators.

ALRI Products now available at Paramount-Supplements.com!

CEE: King Amongst Creatines!

Unless you have been living in a cave in some far off land for the last decade, you are fully aware of the astonishing muscle-enhancing, strength-inducing effects of Creatine. After years of continuous tweaking and touch-ups of the creatine molecule the most effective creatine analog by far to be brought to the sports supplement market has been the creatine ethyl esters. This is obviously due to their very unique ability to be nearly 100% orally active (creatine monohydrate is about 30% orally active in the best of environments) and their very high affinity for muscle tissue even without any of the carbohydrates or other compounds needed to make it work. Yup, this means more muscle building and performance potential than ever before?and creatine ethyl ester is king here! Take a look see...

* Dramatic increased muscle size, lean mass and strength

* Up to 4000% more potent than creatine monohydrate

* Nearly 100% creatine absorption

* Mega- pumps and vascularity

* Greater endurance

* Enhanced recovery

* Zero bloating or water retention.

* No more cramping or stomach upset

Nitric Oxide: The Muscle?s ?Cell Signaling? Molecule!

Sometime in the 80?s a small group of researches discovered the presence of a unique and important gas in humans called nitric oxide (NO2). Known in the world of science as the muscle?s ?cell signaling? molecule, NO2 acts in many tissues to regulate a diverse range of physiological processes, many of which enhance both physique and performance! Supplements that can act to increase NO2 production in the body are some of the most widely used in the world today! And for good reason. Take a look, and you will be a believer...

* Amazing long-lasting pumps?everywhere

* Hastened recovery

* Increased strength and power output

* Improved nutrient transport

* Vascular dilation

* Type-II muscle fiber stimulation

* Enhanced oxygen delivery*Better glucose uptake

The Dream-Team?

The thought process behind teaming up CEE with NO2 potentiators is rock-solid, as increasing nitric oxide levels in the body, while ingesting creatine, would result in increased signaling for muscle cell absorption and even greater muscle growth and performance enhancement due to the synergy involved. However, up until now, the science used to put these physique-transforming wonders together has been haphazard at best. The result? Pissing both your money and your results down the drain!

So What?s the Problem?

I?ll give you the short version...LACK OF RESEARCH! In their haste to be the first to market with creatine/NO2 combination supplements, most companies are simply throwing together creatine and arginine, perhaps along with 1 or 2 other nitric oxide precursors. Well, guess what my friends...research shows that arginine actually inhibits creatine absorption! Read it and weep fellas...

Mitochondrial creatine transport was to a significant part dependent on the energetic state of mitochondria and was inhibited by arginine, and to some extent also by lysine, but not by other creatine analogues and related compounds.

And this statement holds true whether AAKG, arginine-malate, or even AEE (arginine ethyl ester) is used in the formula! Hmmm, no wonder I wasn?t getting any stronger or bigger on creatine/NO2 product ?X, Y, or Z...I wasn?t even absorbing the freaking creatine!!?



Real Science Applied...

Once again, it is Applied Lifescience Research Industries Inc. (ALRI) that steps up to the plate, and hits a grand-slam with the introduction of the first truly synergistic and scientifically formulated CEE/NO2 product on the sports supplementation market...N?Gorge?!

N?Gorge? contains a radical combination of some of the most effective and novel patent pending compounds that the industry has ever witnessed, and it will deliver results that will exceed even your wildest expectations.

-Creatine Ethyl Ester HCI: The state of the industry for highest activity creatine analog. The most absorbable and potent form of creatine developed to date.

-Citrulline malate: Time-release precursor to Nitric Oxide.

-Glutamine Ethyl Ester: Glutamine in its highest nearly 100% bioavailable form will result in greater recovery, cell-volumization, GH release, protein synthesis, immune function, and anti-catabolic effects.

-N(gamma)-hydroxy-L-arginine and N(omega)-hydroxy-nor-L-arginine: Unique hydroxy variants of arginine that radically increase plus prolong the production and level of NO2 in the body significantly, without interfering with the absorption of creatine whatsoever. (Yes, these are the ?other creatine analogues? mentioned above).

-L-Norvaline: Dramatically enhances NO2 production by inhibiting arginase, leaving more arginine available for use by NOS (nitric oxide synthases), which are the enzymes that convert arginine into citrulline, producing NO2 in the process.

The Take Home Message Here?

N?Gorge? is a true innovation that will create an environment within your body pumped and primed for increased performance and muscle growth potential.

The great Arnold once compared the feeling of ?the PUMP? to the feeling of having sex, and nothing will produce a longer or stronger pump than N?Gorge?...fella?s, you do the math! (Yes, it works for women too)

These statements have not been evaluated by the Food & Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

Supplement Facts

N?Gorge? Retail $79

Serving Size: (4) capsule

Amount Per Serving DV%*

Creatine Ethyl Ester HCI 2000mg

Patent Pending Unique Proprietary Nitric Oxide Matrix: 550mg

L-Norvaline, N(gamma) Hydroxy-L-Arginine, N(omega)-nor-L-Hydroxy-L-Arginine, Citrulline Malate, Glutamine Ethyl Ester

Additional Creatine Ethyl Ester Products

Learn more about Nitric Oxide

Learn more about L-Arginine

Learn more about Creatine Ethyl Ester

Find More Discount ALRI Supplements Here

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References:

1) Novel mitochondrial creatine transport activity: Implications for intracellular creatine compartments and bioenergetics Institute of Cell Biology, ETH-Zurich, Zurich CH-8093 Bernd Walzel, Olliver Speer, Else Zanolla, Ove Eriksson, Paolo Bernardi, and Theo Wallimann

2) Am J Physiol Heart Circ Physiol 274: H342-H348, 1998; Vol. 274, Issue 1, H342-H348, January 1998 Arginase modulates nitric oxide production in activated macrophages. Chiung-I Chang1, James C. Liao2, and Lih Kuo1 Department of Medical Physiology, Microcirculation Research Institute, Texas A&M University Health Science Center, College Station, Texas 77843-1114; and 2 Department of Chemical Engineering, University of California, Los Angeles, California 90095-1592

3) Nitric Oxide. 1999 Dec;3(6):427-38. Effects of the new arginase inhibitor N(omega)-hydroxy-nor-L-arginine on NO synthase activity in murine macrophages. Tenu JP, Lepoivre M, Moali C, Brollo M, Mansuy D, Boucher JL. UMR 8619 CNRS, Batiment 430, Universite Paris-Sud XI, Orsay Cedex, F-91405, France.

4) Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate: M.A. Marletta, et al.; Biochemistry 27, 8706 (1988) P.L. Feldman; THL 32, 875 (1991)

5) l cells: A. Zembowicz, et al.; PNAS 88, 11172 (1991)

8) N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery: G.C. Wallace, et al.; BBRC 176, 528 (1991)

9) Inhibition of rat liver arginase by an intermediate in NO biosynthesis, NG-hydroxy-L-arginine: implications for the regulation of nitric oxide biosynthesis by arginase: F. Daghigh, et al.; BBRC 202, 174 (1994)

10) N omega-hydroxyl-L-arginine, an intermediate in the L-arginine to nitric oxide pathway, is a strong inhibitor of liver and macrophage arginase: J.-L. Boucher, et al.; BBRC 203, 1614 (1994)

11) Am J Physiol Heart Circ Physiol 274: H342-H348, 1998; Vol. 274, Issue 1, H342-H348, January 1998On the substrate specificity of nitric oxide synthase: M. Hecker, et al.; FEBS Lett. 294, 221 (1991)

6) N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine: D.J. Stuehr, et al.; J. Biol. Chem. 266, 6259 (1991)

7) Nitric oxide and another potent vasodilator are formed from NG-hydroxy- L-arginine by cultured endothelia Arginase modulates nitric oxide production in activated macrophages

12) Bendahan D, Mattei JP, Ghattas B, et al. 2002. Citrulline/malate promotes aerobic energy production in human exercising muscle. Br J Sports Med; 36(4):282-9.

13) Briand J, Blehaut H, Calvayrac R, Laval-Martin D. 1992. Use of a microbial model for the determination of drug effects on cell metabolism and energetics: study of citrulline-malate. Biopharm Drug Dispos; 13(1):1-22.

14) Callis A, Magnan de Bornier B, Serrano JJ, et al. 1991.Activity of citrulline malate on acid-base balance and blood ammonia and amino acid levels. Study in the animal and in man. Arzneimittelforschung; 41(6):660-3.

15) Fornaris E, Vanuxem J, Duflot P, et al. 1984. [Pharmacological/clinical approach of citrulline malate activity: study of blood lactate levels during standardized muscular exercise]. Gazette Medicale, 91(11):125-128.

16) Goubel F, Vanhoutte C, Allaf O, et al. 1997. Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins. Can J Physiol Pharmacol; 75(3):205-7.

17) Hartman WJ, Torre PM, Prior RL. 1994. Dietary citrulline but not ornithine counteracts dietary arginine deficiency in rats by increasing splanchnic release of citrulline. J Nutr; 124(10):1950-60.

18) Janeira MA, Santos PJ. 1998. Citrulline malate effects on the aerobic-anaerobic threshold and in post-exercise blood lactate recovery. Med Sci Sports Exerc; 30(5 supp): abstract 881.

19) Vanuxem D, Duflot JC, Prevot H, et al. 1990. [Influence of an anti-astenia agent, citrulline malate, on serum lactate and ammonia kinetics during a maximum exercise test in sedentary subjects]. Sem Hop Paris; 66(9):477-481.

20) Waugh WH, Daeschner CW, Files BA, et al. 2001. Oral citrulline as arginine precursor may be beneficial in sickle cell disease: early phase, two results. J Natl Med Assoc; 93(10):363-71.

21) Schedel JM, Tanaka H, Kiyonaga A, Shindo M, Schutz Y. Acute creatine ingestion in human: consequences on serum creatine and creatinine concentrations. Life Sci 1999 Oct 29;65(23):2463-70

22) Saab G, Marsh GD, Casselman MA, Thompson RT. Changes in human muscle transverse relaxation following short-term creatine supplementation. Exp Physiol 2002 May;87(3):383-9

23) Waldegger S, Busch GL, Kaba NK, Zempel G, Ling H, Heidland A, Haussinger D, Lang F. Effect of cellular hydration on protein metabolism. Miner Electrolyte Metab 1997;23(3-6):201-5