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Additional
Diet Pills & Fat Burners
PHIRE!
is a revolutionary pharmaceutical-grade fat loss formula specifically designed to boost your metabolism and heighten your energy levels. PHIRE's scientifically designed mixture of ingredients are brought together as a powerhouse team to eradicate undesired fat where it matters most! Ground breaking ingredients such as Evodiamine and Forskolin have been shown to utilize stored body fat for energy, naturally increasing the body?s metabolism. In addition,
PHIRE! is formulated with Caffeine, Yohimbe and Tyrosine to increase energy, mental alertness and focus
. Stop spinning your wheels with inefficient fat loss products and upgrade to Axis Labs? PHIRE!?, the Xtreme Metabolic that will make you forget all about ephedra. Get PHIRE! now to help you expose your hardest core ever!
Product Highlights:
Powerful Source of Energy and Increases Mental Alertness and Focus
Decreases Fatigue
Maintains Muscle Tone
Utilizes Stored Body Fat for Fuel
Optimizes Cardiovascular Function [increases capillary dilation]
Suppresses Appetite
Supports Energy Metabolism and Helps the Body with the Breakdown of Fat and Carbohydrates
Supports Thyroid Production to Ramp Up Metabolism
Enhanced Feeling of Well Being
Enhanced Insulin Secretion and Sensitivity
What is PHIRE!? made up of that makes it such a powerful fat burning supplement?
Evodiamine
Evodiamine is a bioactive alkaloid extract from a plant called Evodiae Fructus. This is a Chinese herb named Wu-Chu-Yu that Chinese herbalists have used for centuries as a weight loss supplement. Evodiamine is related to capsaicin or the spicy flavor of peppers. It acts as a vanilloid receptor agonist, and can enhance lipolytic (breakdown of fat) activity, enhance insulin secretion and sensitivity.
Interestingly enough, Evodiamine can raise the body?s skin temperature while simultaneously decreasing core temperature, similar to a hypothermic state. Studies have shown that this is an effective process to burn calories and fat for energy while the body increases its temperature.
Forskolin
Froskolin is a diterpene found in the root of an Indian plant called Coleus Forskohlii (part of the mint family of plants). In the body, Forskolin activates an enzyme that raises levels of a key cell-regulating substance called cAMP (cyclic adenosine monophosphate). Increased cellular cAMP levels cause numerous physiological and biochemical effects such as increased insulin secretion, increased thyroid function (and therefore metabolic rate), reduced adipose assimilation and increased lipolysis (the breakdown of fats). Forskolin can also increase blood flow and capillary dilation.
Thiamine
Thiaming helps support energy metabolism and assists the body with the breakdown of fat, and carbohydrates. Every cell of the body requires vitamin B1 to form ATP from the break down of fat and carbohydrates. Thiamine keeps your mucous membranes healthy and is essential for nervous system, cardiovascular and muscular function, and it also helps maintain muscle tone.
Niacin
Niacin helps support energy metabolism and assists the body with the breakdown of fat, carbohydrates. Niacin helps fuel your body by converting blood sugar into energy, and assists in the release of energy from the metabolism of carbohydrates, fats, and proteins. Niacin is also necessary for the synthesis of secondary sex hormones.
Yohimbine
Yohimbine, an alkaloid, is the primary active ingredient of yohimbe. Yohimbine increases the amount of adrenergic activity in the body, increasing levels of norepinephrine and stimulation of the central nervous system. In addition, Yohimbine has shown to increase lipolysis (the breaking down of fat). Yohimbine has also shown to be an appetite suppressant, potentially reducing caloric intake. It has also been shown to enhance insulin secretion and sensitivity.
caffeine
.
Caffine has Thermogenic properties and increases lipolysis (fat break down). Caffine can suppress appetite, decrease fatigue, and increase alertness and work capacity, which can be very beneficial for endurance exercise. Caffine acts as a stimulant and has a synergistic effect with norepinephrine and other catecholamines like ephedrine and possibly yohimbine. Thermogenic and stimulant effects can be greatly increased through the synergistic effect of caffine.
L-Tyrosine
L-Tyrosine is essential amino acid that is a building block of protein and is necessary for maintaining proper brain function. L-Tyrosine is a precursor to the adrenal hormones norepinephrine, epinephrine, dopamine and to thyroid hormones. Because L-Tyrosine is a precursor of dopamine, supplementing with L-Tyrosine may increase feelings of well being, heighten mental alertness and offset physical and mental fatigue. L-Tyrosine has also show to suppress appetite, potentially reducing caloric intake.
Supplement Facts
Serving Size: 2 Mini-Caps
Servings per Container: 60
Amount Per Serving *%DV
Vitamin B1 (Thiamine) 25mg 1666%
Vitamin B3 (Niacin) 25mg 125%
Caffeine Anhydrous 200mg
Yohimbe (3% Yohimbine) 100mg
Evodiamine 98% 50mg
Coleus Forskohli (40% Forskolin) 50mg
L-Tyrosine 50mg
*Daily value (DV) are based on a 2000 calorie diet Daily value (DV) not established
Other Ingredients: Dicalcium Phosphate, Gelatin, purified water, Magnesium Stearate, Silica.
Directions:
As a dietary supplement, take 1-2 capsules, 30 minutes prior to breakfast and 1-2 capsules in the early afternoon. Do not take 6 hours prior to bed because PHIRE!? may interfere with sleep. For best results, use in conjunction with a reduced caloric diet and cardiovascular exercise program.
Store in a cool place. Protect from heat, light and moisture.
WARNING: KEEP OUT OF REACH OF CHILDREN. Not for use by individuals under the age of 18 or elderly. Consult a physician before using this or any dietary supplements. Do not use if pregnant, nursing or chronically ill. This product is not intended for individuals who are at risk of or have been treated for high blood pressure, heart disease, thyroid disease, depression or other psychiatric condition, renal disease, reoccurring headaches, spasms, has asthma or taking asthma medication or if your are using a MAO inhibitor.
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REFRENCES: Evodiamine 1) Kobayashi, Y., Y. Nakano, M. Kizaki, K. Hoshikuma, Y. Yokoo and T. Kamiya (2001). Capsaicin-like anti-obese activities of evodiamine from fruits of Evodia rutaecarpa, a vanilloid receptor agonist. Planta Med 67(7): 628-33. 2) Komatsu, K., K. Wakame and Y. Kano (1993). Pharmacological properties of galenical preparation. XVI. Pharmacokinetics of evodiamine and the metabolite in rats. Biol Pharm Bull 16(9): 935-8. 3) Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM. (2004). Evodiamine functions as an agonist for the vanilloid receptor TRPV1. Org Biomol Chem. Aug 21;2(16):2281-6. Epub 2004 Jul 27. 4) Tsai, T. H., T. F. Lee, C. F. Chen and L. C. Wang (1995). Thermoregulatory effects of alkaloids isolated from Wu-chu-yu in afebrile and febrile rats. Pharmacol Biochem Behav 50(2): 293-8. Tyrosine 5) Banderet, LE, and Lieberman HR. (1989). Treatment with tyrosine, a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull 22: 759-762. 6) Gelenberg AJ, Gibson CJ, Wojcik JD. (1982). Neurotransmitter precursors for the treatment of depression. Psychopharmacol Bull 18:7-18. 7) Harmer CJ, McTavish SF, Clark L, Goodwin GM, Cowen PJ. (2001). Tyrosine depletion attenuates dopamine function in healthy volunteers. Psychopharmacology (Berl). Feb;154(1):105-11. 8) Hull KM, Maher TJ. (1990). L-tyrosine potentiates the anorexia induced by mixed-acting sympathomimetic drugs in hyperphagic rats. J Pharmacol Exp Ther. Nov;255(2):403-9. 9) Lieberman, HR, Corkin S, Spring BJ, Wurtman RJ, and Growden JH. (1985). The effects of dietary neurotransmitter precursors on human behavior. Am J Clin Nutr 42: 366-370. 10) Roberts SA, Thorpe JM, Ball RO, Pencharz PB. (2001). Tyrosine requirement of healthy men receiving a fixed phenylalanine intake determined by using indicator amino acid oxidation. Am J Clin Nutr. Feb;73(2):276-82. 11) Romanowski, W, and Grabiec S. (1974). The role of serotonin in the mechanism of central fatigue. Acta Physiol Pol 25: 127-134. Caffeine 12) Hespel P, Op't Eijnde B, Van Leemputte M. (2002). Opposite actions of caffeine and creatine on muscle relaxation time in humans. J Appl Physiol. Feb;92(2):513-8. 13) Kourtidou-Papadeli C, Papadelis C, Louizos AL, Guiba-Tziampiri O. (2002). Maximum cognitive performance and physiological time trend measurements after caffeine intake. Cogn Brain Res. May;13(3):407-15. 14) Papadelis C, Kourtidou-Papadeli C, Vlachogiannis E, Skepastianos P, Bamidis P, Maglaveras N, Pappas K. (2003). Effects of mental workload and caffeine on catecholamines and blood pressure compared to performance variations. Brain Cogn. Feb;51(1):143-54. 15) Plaskett CJ, Cafarelli E. (2001). Caffeine increases endurance and attenuates force sensation during submaximal isometric contractions. J Appl Physiol. Oct;91(4):1535-44. Forskolin 16) Borea, P. A., K. Varani, A. Dalpiaz, A. Capuzzo, E. Fabbri and I. J. AP (1994). Full and partial agonistic behaviour and thermodynamic binding parameters of adenosine A1 receptor ligands. Eur J Pharmacol 267(1): 55-61. 17) Chaudhry, A. and J. G. Granneman (1991). Developmental changes in adenylyl cyclase and GTP binding proteins in brown fat. Am J Physiol 261(2 Pt 2): R403-11. 18) Chaudhry, A. and J. G. Granneman (1997). Effect of hypothyroidism on adenylyl cyclase activity and subtype gene expression in brown adipose tissue. Am J Physiol 273(2 Pt 2): R762-7. 19) Deng, C., M. Moinat, L. Curtis, A. Nadakal, F. Preitner, O. Boss, F. Assimacopoulos-Jeannet, J. Seydoux and J. P. Giacobino (1997). Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture. Endocrinology 138(2): 548-52. 20) Dolgacheva, L. P., B. B. Abzhalelov, S. J. Zhang, V. P. Zinchenko and G. E. Bronnikov (2003). 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